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Mechanical disassembly of human picobirnavirus like particles indicates that cargo retention is tuned by the RNA-coat protein interaction

Fig. 6 from María J. Rodríguez-Espinosa et al. 2023: Model depicting the RNA cargo retention for each VLP variant. The Δ45-CP VLP structure (A) does not show externalized cargo. The CP VLP structure (B) shows shorter N-terminals compared to the Ht-CP structure (C), which implies less RNA cargo retention compared to the Ht-CP structure. The cartoons in blue, green and pink colors represent coat protein, RNA and N-terminal, respectively. For mechanical fatigue experiments, rectangular AFM cantilevers (NANOSENSORS™, uniqprobe qp-BioAC AFM probes with three different AFM cantilevers per chip) with nominal spring constants of 0.05 and 0.1 N m−1 were used. The AFM cantilevers were calibrated using Sader's method.

The idea of using virus-like particles as nanocarriers for heterologous cargo transport and delivery requires controlling the stability of the container–cargo system.* In particular, the… Read More »Mechanical disassembly of human picobirnavirus like particles indicates that cargo retention is tuned by the RNA-coat protein interaction

A Bis(terpyridine)nickel(II)-Based Coordination Nanosheet: A Redox-Active Materials with Flexibility and Transparency

Fig. 2f from Kenji Takada et al. 2024 “A Bis(terpyridine)nickel(II)-Based Coordination Nanosheet: A Redox-Active Material with Flexibility and Transparency” Synthesis and morphology identification of 1-Ni. f Topographic AFM image of 1-Ni on a flat Si substrate and the cross-sectional analysis inset For the full figure please refer to the cited article. NANOSENSORS PointProbe Plus® PPP-NCL AFM probes were used for the characterization with atomic force microscopy.

Since the discovery of graphene, extensive studies have revealed various types of novel two-dimensional polymers such as transition metal dichalcogenides, covalent organic frameworks, and carbon… Read More »A Bis(terpyridine)nickel(II)-Based Coordination Nanosheet: A Redox-Active Materials with Flexibility and Transparency