Genetic and environmental factors are key drivers regulating organismal lifespan but how these impact healthspan is less well understood. Techniques capturing biomechanical properties of tissues… Read More »Mechanical properties measured by atomic force microscopy define health biomarkers in ageing C. Elegans
MeCP2 and MBD2 are members of a family of proteins that possess a domain that selectively binds 5-methylcytosine in a CpG context. Members of the… Read More »DNA looping by two 5-methylcytosine-binding proteins quantified using nanofluidic devices
Mechanical forces have emerged as coordinating signals for most cell functions. Yet, because forces are invisible, mapping tensile stress patterns in tissues remains a major… Read More »A tension-adhesion feedback loop in plant epidermis
“Animal cells undergo rapid rounding during mitosis, ensuring proper chromosome segregation, during which an outward rounding force abruptly increases upon prometaphase entry and is maintained… Read More »Cdk1-mediated DIAPH1 phosphorylation maintains metaphase cortical tension and inactivates the spindle assembly checkpoint at anaphase
“Cell membrane roughness has been proposed as a sensitive feature to reflect cellular physiological conditions”* In the article “Substrate properties modulate cell membrane roughness by… Read More »Substrate properties modulate cell membrane roughness by way of actin filaments
New interesting publication by Macrea et. al mentioning the use of NANOSENSORS uniqprobe qp-BioAC: “Hemostasis requires conversion of fibrinogen to fibrin fibers that generate a… Read More »A fibrin biofilm covers blood clots and protects from microbial invasion
Do you have a Keysight, Agilent or Molecular Imaging Atomic Force Microscope in your lab? Are you using MAC Mode (Keysight Technologies’ patented magnetic AC… Read More »MAC Mode Cantilevers for Keysight, Agilent and Molecular Imaging AFMs now available from NANOSENSORS