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SPM探针

Mechanical disassembly of human picobirnavirus like particles indicates that cargo retention is tuned by the RNA-coat protein interaction

Fig. 6 from María J. Rodríguez-Espinosa et al. 2023: Model depicting the RNA cargo retention for each VLP variant. The Δ45-CP VLP structure (A) does not show externalized cargo. The CP VLP structure (B) shows shorter N-terminals compared to the Ht-CP structure (C), which implies less RNA cargo retention compared to the Ht-CP structure. The cartoons in blue, green and pink colors represent coat protein, RNA and N-terminal, respectively. For mechanical fatigue experiments, rectangular AFM cantilevers (NANOSENSORS™, uniqprobe qp-BioAC AFM probes with three different AFM cantilevers per chip) with nominal spring constants of 0.05 and 0.1 N m−1 were used. The AFM cantilevers were calibrated using Sader's method.

The idea of using virus-like particles as nanocarriers for heterologous cargo transport and delivery requires controlling the stability of the container–cargo system.* In particular, the… Read More »Mechanical disassembly of human picobirnavirus like particles indicates that cargo retention is tuned by the RNA-coat protein interaction

Rapid access to discrete and monodisperse block co-oligomers from sugar and terpenoid toward ultrasmall periodic nanostructures

Fig. 4 from : Rapid access to discrete and monodisperse block co-oligomers from sugar and terpenoid toward ultrasmall periodic nanostructures by Takuya Isono et al. Thin-film morphologies of Glc3-b-Sol and Glc4-b-Sol. AFM height images (a, b) and corresponding cross-sectional profiles (c, d) indicating the formation of 6–8-nm-thick horizontal lamellae in Glc3-b-Sol (a, c) and Glc4-b-Sol thin films (b, d). Thin-film samples were prepared by spin-coating the BCO solution onto the hydrophilic surface of a silicon substrate followed by thermal annealing at 85 °C for 1 h. NANOSENSORS PointProbe Plus PPP-NCHR standard silicon tapping mode AFM probes and NANOSENSORS SuperSharpSilicon high resolution silicon AFM probes were used

Discrete block co-oligomers (BCOs) can form highly ordered ultrasmall nanostructures which can be used for lithographic templates. These nanotemplates are promising for the low-cost, large-scale,… Read More »Rapid access to discrete and monodisperse block co-oligomers from sugar and terpenoid toward ultrasmall periodic nanostructures