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tipless cantilevers

Accurate and rapid antibiotic susceptibility testing using a machine learning assisted nanomotion technology platform

Fig. 1 from Alexander Sturm et al. “Accurate and rapid antibiotic susceptibility testing using a machine learning-assisted nanomotion technology platform”: Nanomotion detection and recording platform. a Representation of the components of the nanomotion technology platform. b A representation of the nanomotion measurement setup with the (1) bacteria-loaded cantilever, (2) superluminescent light emitting diode (SLED) = light source, and (3) photodetector. c Schematic illustrating Gram-negative bacteria attached to the cantilever. Prior to attachment, bacteria are dispersed in gelling agarose while the cantilever surface is functionalized using positively charged poly-D-lysine. The gelling agent proved beneficial for an even distribution and stability of the bacterial attachment. d Representative standard 4-h nanomotion recordings with a 2-h medium phase (50% LB medium) followed by a 2-h drug phase with 32 µg/ml CRO for the E. coli reference strains ATCC-25922 (S, susceptible) and BAA-2452 (R, resistant). These recordings form the basis for using nanomotion to conduct AST. This study contains 219 recordings of ATCC-25922 and 225 recordings of BAA-2452 exposed to 32 µg/ml CRO with similar results. Data are available in the source data file. NANOSENSORSTM tipless uniqprobe AFM cantilevers SD-qp-CONT-TL from the NANOSENSORS Special Developments List were used.

Antimicrobial resistance (AMR) has become a significant threat to public health worldwide. * AMR diagnostic strategies such as antibiotic susceptibility testing (AST) help provide clinicians… Read More »Accurate and rapid antibiotic susceptibility testing using a machine learning assisted nanomotion technology platform

Cdk1-mediated DIAPH1 phosphorylation maintains metaphase cortical tension and inactivates the spindle assembly checkpoint at anaphase

NANOSENSORS™ tipless cantilever for various applications in atomic force microscopy and force measurements

“Animal cells undergo rapid rounding during mitosis, ensuring proper chromosome segregation, during which an outward rounding force abruptly increases upon prometaphase entry and is maintained… Read More »Cdk1-mediated DIAPH1 phosphorylation maintains metaphase cortical tension and inactivates the spindle assembly checkpoint at anaphase

Tipless cantilever arrays – Special Development List updated

NANOSENSORS Special Development List has been updated with completely new items: Tipless cantilevers arrays (qp-TL8) based on uniqprobe – uniform quality probe – technology. Similar to the uniqprobe cantilevers (i.e. qp-CONT), the cantilevers of these new arrays show an outstanding uniformity of their thicknesses leading to a strongly reduced dispersion of force constants and resonance frequenices compared with standard silicon cantilever arrays.

tl8-1

Read More »Tipless cantilever arrays – Special Development List updated